microRNAs in Toxicology and Medicine

During the past decade it has become evident that microRNAsregulate gene expressions and control many developmental andcellular processes in eukaryotic organisms. Recent studies suggestthat microRNAs play an important role in toxicogenomics and arelikely to play an important role in a range of human diseasesincluding cancer. microRNAs in Toxicology and Medicine is a comprehensiveand authoritative compilation of up-to-date developments in thisemerging research area, presented by internationally recognizedinvestigators. It focuses on the role of microRNA in biology andmedicine with a special emphasis on toxicology. Divided into six parts, topics covered include: microRNA and toxicology – including environmentaltoxicants and perturbation of miRNA signaling; microRNA, andDisease States featuring microRNAs in drug-induced liver toxicity,microRNAs and Inflammation the regulatory role of microRNA inmutagenesis, microRNAs and cancer, and the role of microRNAs intumor progression and therapy, as well as current understanding ofmicroRNAs as therapeutic targets in cancer microRNAs and disease states microRNAs and stem cells microRNAs and genomics microRNAs and epigenomics microRNAs and biomarkers – including body fluid microRNAsas toxicological biomarkers, cell-free microRNAs as biomarkers inhuman diseases, and circulating microRNAs as biomarkers ofdrug-induced pancreatitis microRNAs in Toxicology and Medicine is an essentialinsight into the current trends and future directions of researchin this rapidly expanding field for investigators, toxicologists,risk assessors, and regulators in academia, medical settings,industry, and government.